Mirena

Generic Name: levonorgestrel (Intrauterine route)

lee-voe-nor-JES-trel

Commonly used brand name(s)

In the U.S.

• Mirena

Available Dosage Forms:

• Insert, Extended Release

Therapeutic Class: Contraceptive, Local

Pharmacologic Class: Progestin

Uses For Mirena

Levonorgestrel-releasing intrauterine system is a device that contains the female hormone, levonorgestrel. It is placed in the uterus (womb) where it slowly releases the hormone to prevent pregnancy for up to five years. It works by stopping a woman's egg from fully developing each month. The egg can no longer accept a sperm and fertilization (pregnancy) is prevented.

Levonorgestrel-releasing intrauterine system is also used to treat heavy menstrual bleeding in women. It works best in women who have had at least one child.

This medicine is available only with your doctor's prescription.

Before Using Mirena

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of levonorgestrel in teenage females. This medicine may be used for birth control in teenage females but is not recommended before the start of menstruation.

Geriatric

Appropriate studies on the relationship of age to the effects of levonorgestrel have not been performed in the geriatric population. This medicine is not recommended for use in elderly women.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	X	Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Isotretinoin


• Theophylline


• Tizanidine


• Tranexamic Acid

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acitretin


• Alprazolam


• Amoxicillin


• Ampicillin


• Amprenavir


• Aprepitant


• Atazanavir


• Bacampicillin


• Betamethasone


• Bexarotene


• Bosentan


• Carbamazepine


• Colesevelam


• Cyclosporine


• Darunavir


• Delavirdine


• Doxycycline


• Efavirenz


• Etravirine


• Fosamprenavir


• Fosaprepitant


• Fosphenytoin


• Griseofulvin


• Lamotrigine


• Licorice


• Minocycline


• Modafinil


• Mycophenolate Mofetil


• Mycophenolic Acid


• Nelfinavir


• Nevirapine


• Oxcarbazepine


• Oxytetracycline


• Phenobarbital


• Phenytoin


• Pioglitazone


• Prednisolone


• Primidone


• Rifabutin


• Rifampin


• Rifapentine


• Ritonavir


• Rosuvastatin


• Rufinamide


• Selegiline


• St John's Wort


• Tacrine


• Telaprevir


• Tetracycline


• Topiramate


• Troglitazone


• Troleandomycin


• Voriconazole


• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Caffeine

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Abnormal or unusual vaginal bleeding or


• Abnormally-shaped uterus or uterine fibroids or


• Breast cancer, known or suspected, or a history of or


• Cancer of the uterus or cervix, known or suspected or


• Infection (e.g., pneumonia, HIV/AIDS) or


• Liver disease, including tumors or cancer or


• Pelvic infection (active or untreated), history of or


• Pelvic inflammatory disease (a serious pelvic infection), or history of—Should not be used in patients with these conditions.

• Bleeding problems or


• Blood clots or


• Diabetes or


• Heart attack, history of or


• Heart disease or other heart problems (e.g., congenital heart disease, heart valve problems) or


• Hypertension (high blood pressure), severe or


• Migraine headaches, severe or


• Stroke, history of—Use with caution. May make these conditions worse.

Proper Use of Mirena

Your doctor will give you this medicine in a hospital or clinic. The intrauterine device (IUD) is inserted into your uterus.

This medicine comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

Your doctor may want to do tests to make sure you do not have an infection before putting in an IUD. The IUD is usually inserted during your monthly period or immediately after a miscarriage or an abortion in the first trimester of your pregnancy. Putting an IUD in during a monthly period also helps to make sure that you are not pregnant. You will also need to see your doctor within four to twelve weeks of having your IUD placed and then once a year.

Levonorgestrel IUD has a string or "tail" which is made of plastic thread. About one or two inches of this string hangs into your vagina. You cannot see this string, and it will not cause problems when you have sex. Check your IUD string every few days during the first few months that you have your IUD. After that, check the string after each monthly period. You may not be protected against pregnancy if you cannot feel the string or if you feel plastic. Do the following to check the placement of your IUD:

• Wash your hands with soap and warm water. Dry them with a clean towel.


• Bend your knees and squat low to the ground.


• Gently put your index (pointing) finger high inside your vagina. The cervix is at the top of the vagina and feels like the tip of your nose. Find the IUD string coming from your cervix. Never pull on the string. You should not be able to feel the firm plastic of the IUD itself.


• Wash your hands after you are finished checking your IUD.

You will need to have your levonorgestrel-releasing IUD replaced every five years, or sooner if it comes out of your uterus.

Precautions While Using Mirena

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and does not cause unwanted effects. These visits will usually be every 4 to 12 weeks after insertion, but some doctors require them more often.

Call your doctor right away if you think you have become pregnant while you are using this medicine. You may have a higher risk of an ectopic pregnancy if you get pregnant while your IUD is in place. An ectopic pregnancy can be a serious and life-threatening condition. It can also cause problems that may make it harder for you to become pregnant in the future.

An IUD can slip partly or all of the way out of your uterus without you knowing it. If this happens, you will have no protection against getting pregnant or you may have an increased risk for serious problems. This is more likely during the first year that you have your IUD, but can happen at any time. Regularly checking the string of your IUD can tell you if your IUD is still in place.

You may have some blood spotting and cramping during the first few weeks after the IUD has been inserted. These symptoms should go away within a few months. Rarely, the IUD may make a hole in the wall of your uterus when it is inserted. If this happens, check with your doctor right away.

An IUD increases your risk of a serious infection of the female organs called pelvic inflammatory disease (PID). PID can be serious, even life threatening. This infection could cause scarring of the female organs, which may make it hard for you to become pregnant in the future, and can increase your risk of ectopic pregnancy.

Call your doctor right away if you have flu-like symptoms, fever, chills, cramps, pain, bleeding, or fluid leaking from your vagina. These may be signs that you have an infection.

This device will not protect you from getting HIV/AIDS, herpes, or other sexually transmitted diseases. Tell your doctor if you or your partner begin to have sexual intercourse with other people, or you or your partner tests positive for a sexually transmitted disease. If this is a concern for you, talk with your doctor.

This medicine may cause changes in your blood sugar levels. Also, this medicine may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Mirena Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Abdominal or pelvic pain


• absent, missed, or irregular menstrual periods


• longer or heavier menstrual periods


• mild bloating


• stopping of menstrual bleeding


• unusually heavy or unexpected menstrual bleeding


• uterine bleeding between menstrual periods


• vaginal bleeding or spotting

Less common

• Blurred vision


• cramps


• dizziness


• headache


• heavy bleeding


• itching of the vagina or genital area


• itching of the vagina or genitals


• nervousness


• pain


• pain during sexual intercourse


• painful sexual intercourse


• pale skin


• pounding in the ears


• slow or fast heartbeat


• swelling


• thick, white vaginal discharge with mild or no odor


• troubled breathing with exertion


• unusual bleeding or bruising


• unusual tiredness or weakness


• white or brownish vaginal discharge

Rare

• Chills


• confusion


• dizziness, lightheadedness, or fainting


• fast heartbeat


• fast, weak pulse


• fever


• pale, cold, clammy skin


• rapid, shallow breathing


• sudden increase in stomach or shoulder pain


• sweating


• unusual or large amount of vaginal bleeding

Incidence not known

• Clear or bloody discharge from nipple


• dimpling of breast skin


• dull or aching abdominal or stomach pain


• foul-smelling vaginal discharge


• increased urge to urinate


• inverted nipple


• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• lump in the breast or under the arm


• pain on urination


• persistent crusting or scaling of the nipple


• redness or swelling of the breast


• severe abdominal or stomach pain or cramping


• sharp pain on insertion


• shivering fever


• sore on the skin of the breast that does not heal


• unexpected, heavy vaginal bleeding

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Blemishes on the skin


• depression


• pimples

Less common

• Back pain


• breast tenderness or pain


• decreased interest in sexual intercourse


• full or bloated feeling


• hair loss


• hives or welts


• increased hair growth, especially on the face


• increased weight


• itching


• loss in sexual ability, desire, drive, or performance


• nausea


• nervousness


• pressure in the stomach


• rash


• redness of the skin


• skin rash, encrusted, scaly, and oozing


• swelling of the abdominal or stomach area


• thinning of the hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Mirena side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Mirena resources

• Mirena Side Effects (in more detail)
• Mirena Use in Pregnancy & Breastfeeding
• Mirena Drug Interactions
• Mirena Support Group
• 437 Reviews for Mirena - Add your own review/rating

• Mirena Prescribing Information (FDA)


• Mirena Consumer Overview


• Mirena IUD MedFacts Consumer Leaflet (Wolters Kluwer)


• Levonorgestrel MedFacts Consumer Leaflet (Wolters Kluwer)


• Levonorgestrel Professional Patient Advice (Wolters Kluwer)


• Next Choice Prescribing Information (FDA)


• Plan B Prescribing Information (FDA)


• Plan B Consumer Overview


• Plan B One-Step Consumer Overview


• Plan B One-Step MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Mirena with other medications

• Abnormal Uterine Bleeding
• Birth Control

Diltiazem Hennig

Diltiazem Hennig may be available in the countries listed below.

Ingredient matches for Diltiazem Hennig

Diltiazem

Diltiazem hydrochloride (a derivative of Diltiazem) is reported as an ingredient of Diltiazem Hennig in the following countries:

• Germany

International Drug Name Search

meprobamate

me-proe-BAM-ate

Commonly used brand name(s)

In the U.S.

• Mb-Tab


• Miltown


• Trancot

Available Dosage Forms:

• Tablet


• Capsule, Extended Release

Therapeutic Class: Antianxiety

Chemical Class: Carbamate

Uses For meprobamate

Meprobamate is used to relieve nervousness or tension. meprobamate should not be used for nervousness or tension caused by the stress of everyday life.

Meprobamate is available only with your doctor's prescription.

Before Using meprobamate

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For meprobamate, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to meprobamate or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on meprobamate have been done only in adult patients, and there is no specific information comparing use of meprobamate in children with use in other age groups.

Geriatric

Elderly people may be especially sensitive to the effects of meprobamate. This may increase the chance of side effects during treatment.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking meprobamate, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using meprobamate with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Adinazolam


• Alfentanil


• Alprazolam


• Amobarbital


• Anileridine


• Aprobarbital


• Bromazepam


• Brotizolam


• Butabarbital


• Butalbital


• Carisoprodol


• Chloral Hydrate


• Chlordiazepoxide


• Chlorzoxazone


• Clobazam


• Clonazepam


• Clorazepate


• Codeine


• Dantrolene


• Diazepam


• Estazolam


• Ethchlorvynol


• Fentanyl


• Flunitrazepam


• Flurazepam


• Fospropofol


• Halazepam


• Hydrocodone


• Hydromorphone


• Ketazolam


• Levorphanol


• Lorazepam


• Lormetazepam


• Medazepam


• Meperidine


• Mephenesin


• Mephobarbital


• Meprobamate


• Metaxalone


• Methocarbamol


• Methohexital


• Midazolam


• Morphine


• Morphine Sulfate Liposome


• Nitrazepam


• Nordazepam


• Oxazepam


• Oxycodone


• Oxymorphone


• Pentobarbital


• Phenobarbital


• Prazepam


• Primidone


• Propoxyphene


• Quazepam


• Remifentanil


• Secobarbital


• Sodium Oxybate


• Sufentanil


• Tapentadol


• Temazepam


• Thiopental


• Triazolam


• Zolpidem

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of meprobamate. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol abuse (or history of) or


• Drug abuse or dependence (or history of)—Dependence on meprobamate may develop

• Epilepsy—The risk of seizures may be increased

• Kidney disease or


• Liver disease—Higher blood levels of meprobamate may occur, increasing the chance of side effects

• Porphyria—Meprobamate may make the condition worse

Proper Use of meprobamate

Take meprobamate only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much is taken, it may become habit-forming.

Dosing

The dose of meprobamate will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of meprobamate. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For regular (short-acting) tablets:
  
  • Adults and children 12 years of age and older: 400 milligrams three or four times a day, or 600 milligrams two times a day.
  
  
  • Children 6 to 12 years of age: 100 to 200 milligrams two or three times a day.
  
  
  • Children up to 6 years of age: Dose must be determined by the doctor.
  
  


• For long-acting dosage forms (extended-release tablets):
  
  • Adults and children 12 years of age or older: 400 to 800 milligrams two times a day, in the morning and at bedtime.
  
  
  • Children 6 to 12 years of age: 200 milligrams two times a day, in the morning and at bedtime.
  
  
  • Children up to 6 years of age: Dose must be determined by the doctor.
  
  

Missed Dose

If you miss a dose of meprobamate, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using meprobamate

If you will be taking meprobamate regularly for a long time:

• Your doctor should check your progress at regular visits.


• Check with your doctor at least every 4 months to make sure you need to continue taking meprobamate.

If you will be taking meprobamate in large doses or for a long time, do not stop taking it without first checking with your doctor. Your doctor may want you to reduce gradually the amount you are taking before stopping completely.

meprobamate will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking meprobamate.

Before you have any medical tests, tell the medical doctor in charge that you are taking meprobamate. The results of some tests, such as the metyrapone test and the phentolamine test, may be affected by meprobamate.

If you think you or someone else may have taken an overdose of meprobamate, get emergency help at once. Taking an overdose of meprobamate or taking alcohol or other CNS depressants with meprobamate may lead to unconsciousness and possibly death. Some signs of an overdose are severe confusion, drowsiness, or weakness; shortness of breath or slow or troubled breathing; slurred speech; staggering; and slow heartbeat.

meprobamate may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to meprobamate before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert .

Meprobamate may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

meprobamate Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common

• Skin rash, hives, or itching

Rare

• Confusion


• fast, pounding, or irregular heartbeat


• sore throat and fever


• unusual bleeding or bruising


• unusual excitement


• wheezing, shortness of breath, or troubled breathing

Symptoms of overdose

• Confusion (severe)


• dizziness or lightheadedness (continuing)


• drowsiness (severe)


• shortness of breath or slow or troubled breathing


• slow heartbeat


• slurred speech


• staggering


• weakness (severe)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Clumsiness or unsteadiness


• drowsiness

Less common

• Blurred vision or change in near or distant vision


• diarrhea


• dizziness or lightheadedness


• false sense of well-being


• headache


• nausea or vomiting


• unusual tiredness or weakness

After you stop using meprobamate, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

• Clumsiness or unsteadiness


• confusion


• convulsions (seizures)


• hallucinations (seeing, hearing, or feeling things that are not there)


• increased dreaming


• muscle twitching


• nausea or vomiting


• nervousness or restlessness


• nightmares


• trembling


• trouble in sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: meprobamate side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More meprobamate resources

• Meprobamate Side Effects (in more detail)
• Meprobamate Use in Pregnancy & Breastfeeding
• Drug Images
• Meprobamate Drug Interactions
• Meprobamate Support Group
• 2 Reviews for Meprobamate - Add your own review/rating

• meprobamate Concise Consumer Information (Cerner Multum)


• Meprobamate Prescribing Information (FDA)


• Meprobamate Professional Patient Advice (Wolters Kluwer)


• Meprobamate MedFacts Consumer Leaflet (Wolters Kluwer)


• Meprobamate Monograph (AHFS DI)

Compare meprobamate with other medications

• Anxiety

Moisture Drops

Generic Name: ocular lubricant (OK yoo lar LOO bri kant)

Brand Names: Artificial Tears, Celluvisc, Clear Eyes CLR, Comfort Tears, Dry Eye Relief, GenTeal, Isopto Tears, Lacri-Lube S.O.P., Lacrisert, Lubricant Eye Drops, Moisture Drops, Oasis Tears, Opti-Free Rewetting Drops, optive, Refresh, Soothe, Sterilube, Systane, Systane Balance, Tears Again, Tears Naturale, Tears Renew, TheraTears, Ultra Fresh, Visine Tears

What is Moisture Drops (ocular lubricant)?

There are many brands and forms of ocular lubricant available and not all are listed on this leaflet.

Ocular lubricant is a solution specially formulated to moisten the eyes.

Ocular lubricant is used to relieve burning, irritation, and discomfort caused by dry eyes.

Ocular lubricant may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Moisture Drops (ocular lubricant)?

There are many brands and forms of ocular lubricant available and not all are listed on this leaflet.

You should not use an ocular lubricant if you are allergic to it. Ocular lubricant will not treat or prevent an eye infection.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have any type of infection in your eye.

Do not allow the dropper or tube tip to touch any surface, including the eyes or hands. If the dropper or tube becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Stop using ocular lubricant and call your doctor if you have severe burning, stinging, irritation, eye pain, or vision changes.

This medication may cause blurred vision. Be careful if you drive or do anything that requires you to be able to see clearly.

Talk with your doctor if your symptoms do not improve or if they get worse while you are using ocular lubricant.

What should I discuss with my healthcare provider before using Moisture Drops (ocular lubricant)?

You should not use an ocular lubricant if you are allergic to it. Ocular lubricant will not treat or prevent an eye infection.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have any type of infection in your eye.

Ocular lubricant is not expected to harm an unborn baby. Ask a doctor or pharmacist about using ocular lubricant if you are pregnant. It is not known whether ocular lubricant passes into breast milk or if it could harm a nursing baby. Ask a doctor or pharmacist about using ocular lubricant if you are pregnant.

How should I use Moisture Drops (ocular lubricant)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Do not use this medication while wearing contact lenses. Eye medication may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using this medication before putting your contact lenses in. Wash your hands before using ocular lubricant.

To apply the eye drops:

• 
  

  Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye.

  
  


• 
  

  Use only the number of drops your doctor has prescribed.

  
  


• 
  

  Gently press your finger to the inside corner of the eye (near your nose) for about 1 minute to keep the liquid from draining into your tear duct. If you use more than one drop in the same eye, wait about 5 minutes before putting in the next drop.

  
  


• 
  

  Do not use the eye drops if the liquid has changed colors or has particles in it.

  
  

To apply the ointment:

• 
  

  Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the ointment tube with the tip pointing toward this pocket. Look up and away from the tip.

  
  


• 
  

  Squeeze out a ribbon of ointment 1/2-inch long into the lower eyelid pocket without touching the tip of the tube to your eye. Look down and close your eyes for a few minutes. Rolling your eyes around gently will help spread the ointment evenly.

  
  


• 
  

  After opening your eyes, you may have blurred vision for a short time. Avoid driving or doing anything that requires you to be able to see clearly.

  
  

Do not allow the dropper or tube tip to touch any surface, including the eyes or hands. If the dropper or tube becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Talk with your doctor if your symptoms do not improve or if they get worse while you are using ocular lubricant. Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle or tube tightly closed when not in use.

What happens if I miss a dose?

Since ocular lubricant is used on an as needed basis, you are not likely to miss a dose.

What happens if I overdose?

An overdose of ocular lubricant is not expected to be dangerous.

What should I avoid while using Moisture Drops (ocular lubricant)?

This medication may cause blurred vision. Be careful if you drive or do anything that requires you to be able to see clearly.

Avoid using other medications in your eyes during treatment with ocular lubricant unless your doctor tells you to.

Moisture Drops (ocular lubricant) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using ocular lubricant and call your doctor if you have a serious side effect such as:

• 
  

  severe burning, stinging, or eye irritation after using the medication;

  
  


• 
  

  eye pain; or

  
  


• 
  

  vision changes.

  
  

Less serious side effects may include:

• 
  

  mild eye burning or irritation;

  
  


• 
  

  itching or redness of your eyes;

  
  


• 
  

  watery eyes;

  
  


• 
  

  blurred vision; or

  
  


• 
  

  unpleasant taste in your mouth.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Moisture Drops (ocular lubricant)?

It is not likely that other drugs you take orally or inject will have an effect on ocular lubricant used in the eyes. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More Moisture Drops resources

• Moisture Drops Use in Pregnancy & Breastfeeding
• Moisture Drops Support Group
• 0 Reviews for Moisture - Add your own review/rating

• FreshKote Drops MedFacts Consumer Leaflet (Wolters Kluwer)


• Genteal Advanced Consumer (Micromedex) - Includes Dosage Information


• Lacri-Lube S.O.P. Ointment MedFacts Consumer Leaflet (Wolters Kluwer)


• Lacrisert Prescribing Information (FDA)


• Lacrisert Insert MedFacts Consumer Leaflet (Wolters Kluwer)


• Lacrisert Advanced Consumer (Micromedex) - Includes Dosage Information


• Murine Tears Drops MedFacts Consumer Leaflet (Wolters Kluwer)


• Murocel Eye Drops MedFacts Consumer Leaflet (Wolters Kluwer)


• Refresh Redness Relief Drops MedFacts Consumer Leaflet (Wolters Kluwer)


• Refresh liquigel

Compare Moisture Drops with other medications

• Eye Dryness/Redness

Where can I get more information?

• Your pharmacist can provide more information about ocular lubricant.

Adco-Cimetidine

Adco-Cimetidine may be available in the countries listed below.

Ingredient matches for Adco-Cimetidine

Cimetidine

Cimetidine is reported as an ingredient of Adco-Cimetidine in the following countries:

• South Africa

International Drug Name Search

SimvaAPS

SimvaAPS may be available in the countries listed below.

Ingredient matches for SimvaAPS

Simvastatin

Simvastatin is reported as an ingredient of SimvaAPS in the following countries:

• Germany

International Drug Name Search

Marplan

Pronunciation: eye-soe-kar-BOX-a-zid
Generic Name: Isocarboxazid
Brand Name: Marplan

Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using Marplan outweigh the risks.

Family and caregivers must closely watch patients who take Marplan. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor.

Marplan is used for:

Treating short-term (up to 6 weeks) depression in patients who do not respond to other medications. It may also be used for other conditions as determined by your doctor.

Marplan is a monoamine oxidase (MAO) inhibitor. It works by increasing certain chemicals in the brain that help elevate mood.

Do NOT use Marplan if:

• you are allergic to any ingredient in Marplan


• you have high blood pressure, heart or brain blood vessel disease or problems, heart failure, liver problems, severe kidney problems, severe or frequent headache, an adrenal gland tumor (pheochromocytoma), or schizophrenia


• you will be having surgery


• you are eating cheese or other foods with a high tyramine content, are taking high amounts of caffeine, or you abuse alcohol


• you are taking an anorexiant (eg, phentermine), an antihypertensive (eg, hydrochlorothiazide), apraclonidine, bupropion, buspirone, carbamazepine, cyclobenzaprine, dextromethorphan, ethanol, levodopa, meperidine, methotrimeprazine, methylphenidate, nefazodone, propoxyphene, a selective serotonin reuptake inhibitor (SSRI) (eg, fluoxetine), a serotonin-norepinephrine reuptake inhibitor (SNRI) (eg, atomoxetine), sibutramine, a sympathomimetic (eg, albuterol, amphetamine), a tetracyclic antidepressant (eg, trazodone), or a tricyclic antidepressant (eg, amitriptyline)


• you are taking or have taken linezolid, methylene blue, or another MAO inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Video: Treatment for Depression

Treatments for depression are getting better everyday and there are things you can start doing right away.

Before using Marplan:

Some medical conditions may interact with Marplan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have asthma, mental or mood disorders (eg, bipolar mood disorder), bronchitis, an irregular heartbeat, diabetes, epilepsy, thyroid problems, certain types of heart disease, Parkinson disease, the blood disorder porphyria, kidney problems, stroke, or suicidal thoughts or behaviors

Some MEDICINES MAY INTERACT with Marplan. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Apraclonidine, bupropion, buspirone, carbamazepine, cyclobenzaprine, dextromethorphan, ethanol, meperidine, methotrimeprazine, phenothiazines (eg, thioridazine), propoxyphene, SNRIs (eg, atomoxetine), or tricyclic antidepressants (eg, amitriptyline) because side effects such as high blood pressure may be increased


• Antihypertensives (eg, hydrochlorothiazide), anorexiants (eg, phentermine), catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), insulin, levodopa, meglitinide antidiabetics (eg, repaglinide), methylphenidate, sibutramine, SSRIs (eg, fluoxetine), sulfonylureas (eg, glipizide), sumatriptan, sympathomimetics (eg, albuterol, amphetamine), tetracyclic antidepressants (eg, trazodone), or tramadol because the actions and side effects of these medicines may be increased


• Disulfiram, linezolid, methylene blue, nefazodone, other MAO inhibitors (eg, phenelzine), or tryptophan because severe unexpected toxicity may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Marplan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Marplan:

Use Marplan as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Marplan comes with an additional patient information sheet called a Medication Guide. Read it carefully and reread it each time you get Marplan refilled.


• Marplan may be taken with or without food.


• It may take 3 to 6 weeks for you to see the effects of Marplan. Continue taking your medicine during this time.


• Continue to take Marplan even if you feel better. Do not miss any doses.


• If you miss a dose of Marplan, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Marplan.

Important safety information:

• Marplan may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Marplan. Using Marplan alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Avoid drinking alcohol or taking other medicines that cause drowsiness (eg, sedatives, tranquilizers) while taking Marplan. Marplan will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.


• Marplan may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.


• Children, teenagers, and young adults who take Marplan may be at increased risk for suicidal thoughts or actions. Watch all patients who take Marplan closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.


• Avoid large amounts of caffeine-containing foods and beverages, such as coffee, tea, cocoa, cola drinks, and chocolate. If you have questions about how much is excessive, ask your doctor.


• Marplan may cause serious increases in blood pressure if certain foods are eaten. Avoid eating foods such as aged cheeses, sour cream, red wines, beer, bologna, pepperoni, salami, summer sausage, pickled herring, liver, meat prepared with tenderizers, canned figs, raisins, bananas, avocados, soy sauce, fava beans, or yeast extracts. Obtain a complete list of foods and beverages from your doctor or pharmacist.


• Additional monitoring of your condition is recommended at the start of treatment with Marplan and whenever a change to your dose is made.


• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Marplan.


• Diabetes patients - Marplan may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.


• Use Marplan with caution in the ELDERLY because they may be more sensitive to its effects.


• Marplan is not recommended for use in CHILDREN younger than 16 years of age. Safety and effectiveness in this age group have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Marplan during pregnancy. It is unknown if Marplan is excreted in breast milk. If you are or will be breast-feeding while you are using Marplan, check with your doctor or pharmacist to discuss the risks to your baby.

When used for long periods of time or at high doses, some people develop a need to continue taking Marplan. This is known as DEPENDENCE or addition.

If you suddenly stop taking Marplan you may experience WITHDRAWAL symptoms including anxiety; confusion; depression; diarrhea; hallucinations; headaches; restlessness; and weakness.

Possible side effects of Marplan:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal skin sensations; anxiety; blurred vision; chills; constipation; diarrhea; dizziness; drowsiness; dry mouth; fainting; forgetfulness; frequent urination; headache; heavy feeling; hyperactivity; inability to urinate; lack of energy; lightheadedness when rising from a seated or lying position; muscle jerks; nausea; sedation; sleep disturbance; sleeplessness; tremors; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; chest pain; cold, clammy skin; difficulty sleeping; fast or irregular heartbeat; feelings of irritability or hostility; impotence; impulsive behavior or other unusual change in behavior; nausea; neck stiffness; panic attacks; pounding in the chest; sensitivity to light; severe headache; severe high blood pressure; severe nervousness or anxiety; severe restlessness; suicidal thoughts or behaviors; sweating; tightness in the throat or chest; vomiting; widened pupils; worsening feelings of depression; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Marplan side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; anxiety; cold, clammy skin; coma; confusion; difficulty breathing; dizziness; drowsiness; excitement; faintness; fast breathing; fast heartbeat; fever; flushing; hallucinations; headache; high blood pressure with a severe headache; hyperactivity; incoherence; irritability; jaw stiffness; low blood pressure; movement disorders including grimacing and rigidity; restlessness; seizures; shock; sleeplessness; sweating; unusual muscle movements; weakness.

Proper storage of Marplan:

Store Marplan at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Marplan out of the reach of children and away from pets.

General information:

• If you have any questions about Marplan, please talk with your doctor, pharmacist, or other health care provider.


• Marplan is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Marplan. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Marplan resources

• Marplan Side Effects (in more detail)
• Marplan Use in Pregnancy & Breastfeeding
• Drug Images
• Marplan Drug Interactions
• Marplan Support Group
• 2 Reviews for Marplan - Add your own review/rating

• Marplan Prescribing Information (FDA)


• Marplan Concise Consumer Information (Cerner Multum)


• Marplan Advanced Consumer (Micromedex) - Includes Dosage Information


• Isocarboxazid Professional Patient Advice (Wolters Kluwer)

Compare Marplan with other medications

• Depression